Product Code: GFC0533
| Catalog Number | Unit Size | Price |
|---|---|---|
| GFC0533-10µg | 10µg | Online Inquiry |
| GFC0533-50µg | 50µg | Online Inquiry |
| GFC0533-100µg | 100µg | Online Inquiry |
| GFC0533- 250µg | 250µg | Online Inquiry |
| GFC0533-500µg | 500µg | Online Inquiry |
| GFC0533-1mg | 1mg | Online Inquiry |
Description
Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine that activates NF-kB, MAPK, and PI3K/AKT pathways. Activated T cells and macrophages are the primary producers of TNF-α in response to inflammation and infectious conditions. Many other cell types have been shown to produce TNF-α, among them B cells, NK cells, mast cells, neutrophils, dendritic cells, microglia, endothelial cells, smooth muscle cells, cardiomyocytes, and fibroblasts. TNF-α has cytotoxic effects on cancer cells in vitro by stimulating anti-tumor immuno- suppressive responses. TNF-α stimulates expression of E- and P-selectins, thus facilitating adhesion of neutrophils, monocytes, and memory T cells to activated platelets and endothelial cells (Zelová & Hosek). Other effects of TNF-α include vasodilatation and edema formation. This product is animal component-free.
Specification
