Cytokines

Human TGFA

Product Code: GFC0149

Description

Transforming growth factor alpha (TGFA) a member of the epidermal growth factor (EGF) family that is expressed in normal epithelial cells, monocytes, macrophages, brain cells, keratinocytes, and cancer cells. TGFA binds EGF receptor (EGFR) and activates tyrosine kinase signaling. In epidermal and epithelial cells, this results in proliferation and differentiation.

Specification

Source

E. coli

Symbols

ETGF, Sarcoma growth factor, TGF, TGF-α, TGF-type I, Transforming growth factor-alpha

Accession

KAI2523774.1

AA Sequence

VVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLA

Molecular Mass

5.6 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by a cell proliferation assay using BALB/c 3T3 cells is ≥ 5.0 x 10^6 units/mg (EC50 ≤ 0.2 ng/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.