Cytokines

Human SHH

Product Code: GFC0147

Description

Sonic hedgehog (SHH) is a member of the Hedgehog family of secreted signaling proteins that has a prominent role in patterning during early mammalian development. During patterning of the central nervous system, SHH directly acts on cells to specify neural cell fates, regulates proliferation and survival of oligodendrocytes precursors and neural crest cells and stimulates proliferation, differentiation and axon growth. SHH also regulates T cell differentiation and activation.

Specification

Source

E. coli

Symbols

HHG-1, HLP3, HPE3, MCOPCB5, SMMCI, Sonic hedgehog, TPT, TPTPS

Accession

Q15465

AA Sequence

IIGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGG

Molecular Mass

19.7 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by inducing alkaline phosphatase production of C3H/10T1/2 (CCL-226) cells is ≥ 500 units/mg (EC50 ≤ 2 μg/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.