Cytokines

Human MSTN

Product Code: GFC0128

Description

Myostatin (MYSTN) is a member of transforming growth factor beta (TGF-β) superfamily that signals by binding to activin type II receptor, resulting in the recruitment of either ALK3 or ALK4 coreceptor, and activation of SMAD2/3. MYSTN appears to affect the lipid catabolic metabolism of adipocytes and inhibits preadipocyte differentiation, as demonstrated in the 3T3-L1 cell line.

Specification

Source

E. coli

Symbols

GDF-8, Growth differentiation factor 8, MSTN78, MSLHP

Accession

O14793

AA Sequence

DFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS

Molecular Mass

12.4 kDa monomer, 24.8 kDa dimer

Purity

≥ 95%

Bioactivity

The specific activity as determined by a cytotoxicity assay using MPC-11 cells is ≥ 2.0 x 10^4 units/mg (EC50 ≤ 50 ng/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.