Cytokines

Human INHBA, animal component-free

Product Code: GFC0117

Description

Inhibin subunit beta A (INHBA) is a member of the transforming growth factor beta (TGF-β) family of proteins produced by many cell types throughout development. It is a disulfide-linked homodimer (two beta-A chains) that binds to heteromeric complexes of a type I (Act RI-A and Act RI-B) and a type II (Act RII-A and Act RII-B) serine-threonine kinase receptor. Activins primarily signal through SMAD2/3 proteins to regulate a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, and metabolism. INHBA maintains the undifferentiated state of human embryonic stem cells and also facilitates differentiation of human embryonic stem cells into definitive endoderm.

Specification

Source

E. coli

Symbols

Activin beta-A chain, EDF, Erythroid differentiation protein, FRP, FSH-releasing protein, INHBA, Inhibin betaA chain, Inhibin beta-1

Accession

P08476

AA Sequence

MGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS

Molecular Mass

13.1 kDa monomer; 26.2 kDa dimer

Purity

≥ 95%

Bioactivity

The EC50 as determined by a cell proliferation assay using MPC-11 cells is ≤ 10 ng/mL.

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.