Cytokines

Human IL-6RA

Product Code: GFC0111

Description

Interleukin 6 receptor alpha (IL-6RA) is a type I transmembrane glycoprotein that forms a complex with type I transmembrane signal transducer protein gp130 (CD130) and mediates the biological activities of IL-6. IL-6 binds to the membrane-bound non-signaling IL-6 receptor alpha, and the complex binds to two molecules of gp130 and leads to 'classical' IL-6-signal transduction, which includes activation of JAK/STAT, ERK, and PI3K signal transduction pathways.

Specification

Source

CHO

Symbols

B cell stimulatory factor-2, CD126, HIES5, IL-1Ra, IL-6R, IL-6R-1, IL-6RA, IL6Q, IL6QTLA, IL6RQ, gp80, IL6R

Accession

P08887

AA Sequence

LAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPVQDSSSVPLP

Molecular Mass

50 - 58 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by the ability to inhibit growth of M1 cells in the presence of 10 ng/mL human IL-6 is ≥ 5 x 10^3 units/mg (EC50 ≤ 200 ng/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.