Recombinant Human IL-6 Protein, E. coli-derived

Product Code: GFC0109

Catalog Number	Unit Size	Price
GFC0109-10 ug	10 ug	Online Inquiry
GFC0109-50 ug	50 ug	Online Inquiry
GFC0109-200 ug	200 ug	Online Inquiry
GFC0109-1 mg	1 mg	Online Inquiry

Description

Interleukin-6 (IL-6) is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. It is produced mainly by T cells, macrophages, monocytes, endothelial cells and muscle cells.
The biological functions of IL-6 are diverse. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. It also acts as a myokine, produced by muscle cells in response to muscle contraction and released into the blood stream to help break down fats and improve insulin resistance.

Specification

Source

E. coli-derived human IL-6 protein, Pro29-Met212

Reactivity

Human

N-terminal Sequence

Pro29

Purity

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Molecular Mass (Predicted)

20.9 kDa

Accession

P05231.1

Biological Activity

Measured in a cell proliferation assay using T1165.85.2.1 mouse plasmacytoma cells. Nordan, R.P. et al. (1987) J. Immunol. 139:813. The ED50 for this effect is 0.2-0.8 ng/mL.

Endotoxin

<0.10 EU per 1 μg of the protein by the LAL method.

Application

Bioactivity

For research or further manufacturing use only. Not for use in humans.