Recombinant Human IL-4

Product Code: GFC0104

Catalog Number	Unit Size	Price
GFC0104-5µg	5µg	Online Inquiry
GFC0104-20µg	20µg	Online Inquiry
GFC0104-50µg	50µg	Online Inquiry
GFC0104-100µg	100µg	Online Inquiry
GFC0104-250µg	250µg	Online Inquiry
GFC0104-500µg	500µg	Online Inquiry
GFC0104-1mg	1mg	Online Inquiry

Description

IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant Human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues.

Specification

Sample Resource

E.coli

Species

Human

Cell Type

B Cells, Dendritic Cells, Hematopoietic Stem and Progenitor Cells, Lymphocytes, Monocytes, Myeloid Cells, Neurons, T Cells

Area of Interest

Immunology, Neuroscience, Stem Cell Biology

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Synonyms

BCGF, BCDF, B cell stimulating factor (BSF-1)

AA Sequence

MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS

Biological Activity

The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.

Calculated Molecular Weight

15.1 kDa

Accession Number

P05112

Gene ID

3565

Endotoxin

Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

For research or further manufacturing use only. Not for use in humans.