Cytokines

Mouse IL-4

Name: Mouse IL-4
SKU: GFC0103

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Product Code: GFC0103

Description

Interleukin 4 (IL-4) is a type I cytokine produced by Th2 T cells, NK T cells, γ/δ T cells, eosinophils, mast cells, and activated basophils. IL-4 plays a key role in immunoglobulin class switching in B cells and in regulating the differentiation of naïve T cells into T helper 2 (Th2) cells, while inhibiting Th1 differentiation. IL-4 acts together with tumor necrosis factor to stimulate expression of adhesion molecules on vascular endothelial cells and to downregulate expression of E-selectin, thus recruiting T cells and eosinophils to the site of inflammation.

Specification

Source

E. coli

Symbols

B cell stimulating factor, BCDF, BCGF, BSF-1, Interleukin-4

Accession

P07750

AA Sequence

MHIHGCDKNHLREIIGILNEVTGEGTPCTEMDVPNVLTATKNTTESELVCRASKVLRIFYLKHGKTPCLKKNSSVLMELQRLFRAFRCLDSSISCTMNESKSTSLKDFLESLKSIMQMDYS

Molecular Mass

13.7 kDa

Purity

≥ 95%

Bioactivity

The EC50 as determined by a cell proliferation assay using HT-2 cells is ≤ 20 ng/mL.

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.

USA

Europe

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