Cytokines

Mouse IL-33

Product Code: GFC0101

Description

Interleukin 33 (IL-33) is a pro-inflammatory cytokine from the IL1 family. It contributes to allergic inflammation by stimulating production of the cytokines IL-4, IL-5, and IL-13 in Th2 cells, and stimulates host defense against microbial and viral infections. In the central nervous system, IL-33 is produced by endothelial cells and astrocytes. It induces proliferation of microglia and mediates production of pro-inflammatory cytokines.

Specification

Source

E. coli

Symbols

IL-1F11, Interleukin-33

Accession

Q8BVZ5

AA Sequence

SIQGTSLLTQSPASLSTYNDQSVSFVLENGCYVINVDDSGKDQEQDQVLLRYYESPCPASQSGDGVDGKKLMVNMSPIKDTDIWLHANDKDYSVELQRGDVSPPEQAFFVLHKKSSDFVSFECKNLPGTYIGVKDNQLALVEEKDESCNNIMFKLSKI

Molecular Mass

17.5 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by a cell proliferation assay using D10S cells is ≥ 2 x 10^6 units/mg (EC50 ≤ 0.5 ng/mL) .

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.