Cytokines

Human IL-1RN

Product Code: GFC0088

Description

Interleukin 1 receptor antagonist (IL-1RN, also known as IL-1RA) is a member of the IL-1 family that binds to IL-1 receptors but does not induce any intracellular signaling. In particular, mesenchymal stem cells have been shown to enhance tissue repair in an IL-1RA-dependent manner through the suppression of IL-1 beta production in dermal macrophages and enhanced expansion of immunosuppressive regulatory T cells in the skin. IL-1RA has also been shown to help in the treatment of rheumatoid arthritis, sepsis, asthma, and inflammatory bowel diseases.

Specification

Source

E. coli

Symbols

DIRA, ICIL-1RA, IL-1F3, IL-1Ra, IL-1ra3, IL-1RN, IL1F3, IL1ra, IL1RN, IRAP, MVCD4, Interleukin 1RA, Interleukin 1 receptor antagonist

Accession

P18510

AA Sequence

MRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE

Molecular Mass

17.3 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by inhibition of human IL-1 alpha-induced proliferation of D10.G4.1 cells is ≥ 2.0 x 10^4 units/mg (EC50 ≤ 50 ng/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.