Cytokines

Mouse IL-1 beta

Product Code: GFC0087

Description

Interleukin 1 beta (IL-1 beta) is a member of the interleukin 1 cytokine family. IL-1 beta is released by monocytes, tissue macrophages, and dendritic cells in response to infection or injury and induces expression of acute-phase proteins. It also promotes the infiltration of inflammatory and immunocompetent cells from the circulation into the extravascular space and affected tissues, by stimulating the expression of adhesion molecules on endothelial cells. IL-1 beta also affects other immune cells; for example, it co-stimulates T cell functions together with antigen or mitogen. It also stimulates Th17 differentiation and B cell proliferation in an IL-6-dependent manner.

Specification

Source

E. coli

Symbols

Catabolin, Endogenous pyrogen, EP, Interleukin-1 beta, LAF, LEM, Leukocyte endogenous mediator, Lymphocyte-activating factor, MCF, Mononuclear cell factor

Accession

P10749

AA Sequence

MVPIRQLHYRLRDEQQKSLVLSDPYELKALHLNGQNINQQVIFSMSFVQGEPSNDKIPVALGLKGKNLYLSCVMKDGTPTLQLESVDPKQYPKKKMEKRFVFNKIEVKSKVEFESAEFPNWYISTSQAEHKPVFLGNNSGQDIIDFTMESVSS

Molecular Mass

17.5 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by a cell proliferation assay using D10S cells is ≥ 5 x 10^8 units/mg (EC50 ≤ 2 pg/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.