Cytokines

Mouse IL-19

Product Code: GFC0084

Description

Interleukin 19 (IL-19) is a member of the IL-10 cytokine family and is produced by keratinocytes, B cells, and monocytes. IL-19 is considered to be a proinflammatory cytokine, as it upregulates IL-6 and tumor necrosis factor alpha (TNF-α). IL-19 also induces T-helper cell differentiation towards a Th2 response, resulting in the production of IL-10 and additional IL-19. IL-19 has been implicated in aging, vascular disease, Type I diabetes, and rheumatoid arthritis.

Specification

Source

E. coli

Symbols

IL-10C, Interleukin-19, MDA1, Melanoma differentiation-associated protein-like protein, NG.1, ZMDA1

Accession

Q8CJ70

AA Sequence

MLRRCLISVDMRLIEKSFHEIKRAMQTKDTFKNVTILSLENLRSIKPGDVCCMTNNLLTFYRDRVFQDHQERSLEVLRRISSIANSFLCVQKSLERCQVHRQCNCSQEATNATRIIHDNYNQLEVSSAALKSLGELNILLAWIDRNHLETPAA

Molecular Mass

17.7 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by a cell proliferation assay using MCF-7 cells is ≥ 2.0 x 10^4 units/mg (EC50 ≤ 50 ng/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.