Animal-Free Recombinant Human IL-10

Product Code: GFC0073

Catalog Number Unit Size Price
GFC0073-2µg 2µg Online Inquiry
GFC0073-10µg 10µg Online Inquiry
GFC0073-50µg 50µg Online Inquiry
GFC0073-100µg 100µg Online Inquiry
GFC0073-250µg 250µg Online Inquiry
GFC0073-500µg 500µg Online Inquiry
GFC0073-1mg 1mg Online Inquiry

Description

IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNF-α. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 is active on murine cells, but murine IL-10 is inactive on human cells. Recombinant Human IL-10 is an 18.6 kDa protein of 161 amino acid residues.

Specification

Sample Resource
E.coli
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Synonyms
B-TCGF, CSIF, TGIF
AA Sequence
MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N
Biological Activity
Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The ED50 was found to be ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
Calculated Molecular Weight
18.6 kDa
Accession Number
P22301
Gene ID
3586
Endotoxin
Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)
For research or further manufacturing use only. Not for use in humans.

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