Animal-Free Recombinant Human IL-10

Product Code: GFC0073

Catalog Number	Unit Size	Price
GFC0073-2µg	2µg	Online Inquiry
GFC0073-10µg	10µg	Online Inquiry
GFC0073-50µg	50µg	Online Inquiry
GFC0073-100µg	100µg	Online Inquiry
GFC0073-250µg	250µg	Online Inquiry
GFC0073-500µg	500µg	Online Inquiry
GFC0073-1mg	1mg	Online Inquiry

Description

IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNF-α. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 is active on murine cells, but murine IL-10 is inactive on human cells. Recombinant Human IL-10 is an 18.6 kDa protein of 161 amino acid residues.

Specification

Sample Resource

E.coli

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Synonyms

B-TCGF, CSIF, TGIF

AA Sequence

MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N

Biological Activity

Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The ED50 was found to be ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Calculated Molecular Weight

18.6 kDa

Accession Number

P22301

Gene ID

3586

Endotoxin

Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

For research or further manufacturing use only. Not for use in humans.