Recombinant Human IFN-β

Product Code: GFC0063

Catalog Number	Unit Size	Price
GFC0063-5µg	5µg	Online Inquiry
GFC0063-20µg	20µg	Online Inquiry
GFC0063-50µg	50µg	Online Inquiry
GFC0063-100µg	100µg	Online Inquiry
GFC0063-250µg	250µg	Online Inquiry
GFC0063-500µg	500µg	Online Inquiry
GFC0063-1mg	1mg	Online Inquiry

Description

Interferon beta (IFN-β), also known as type I interferon, is produced by fibroblasts, and in smaller amounts by plasmocytoid dendritic cells. Macrophages and endothelial cells secrete IFN-β in response to a viral infection (Reder & Feng). IFN-β binds to a receptor complex composed of IFNAR1 and IFNAR2, and initiates signal transduction via the JAK/STAT pathway; this culminates in the transcription and activation of many genes that control dendritic cell activation, T cell survival, NK cell activation, chemokine expression, lymph node retention, and antiproliferative and antiviral effects (Dunn et al.). IFN-β is a first-line treatment for multiple sclerosis. It suppresses Th17 cells by affecting expression of IL-4, IL-10, and IL-27. IFN-β was also shown to expand regulatory T cells and limit T cell trafficking to the central nervous system (Inoue & Shinohara). Out of the two variants of IFN-β (IFN-β1 and IFN-β3), this product is the IFN-β1 form.

Specification

Sample Resource

CHO cells

Species

Human

Cell Type

B Cells, Cancer Cells and Cell Lines, NK Cells, T Cells

Area of Interest

Cancer, Immunology

Formula Category

≥ 95%

Purity

≥ 95% by SDS-PAGE gel and HPLC analyses.

Synonyms

Fibroblast Interferon, IFNB1, Type I Interferon

AA Sequence

MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN

Biological Activity

Determined by a cytotoxicity assay using human TF-1 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.

Calculated Molecular Weight

20 kDa

Accession Number

P01574

Gene ID

For research or further manufacturing use only. Not for use in humans.

USA

Europe

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