Cytokines

Human DKK1, His tag

Product Code: GFC0035

Description

DKK1 is a member of the Dickkopf family and is a secreted protein that inhibits the canonical WNT pathway by competitive binding to low-density lipoprotein receptors (LRP)-5 and 6 with high affinity, thereby decreasing β-catenin protein stability (Niehrs). DKK1 plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines.

Specification

Source

HEK293

Tag

His

Symbols

Dickkopf-1, hDkk-1, SK, Dickkopf WNT signaling pathway inhibitor 1

Accession

O94907

AA Sequence

TLNSVLNSNAIKNLPPPLGGAAGHPGSAVSAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLACRKRRKRCMRHAMCCPGNYCKNGICVSSDQNHFRGEIEETITESFGNDHSTLDGYSRRTTLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLEIFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRHHHHHHH

Molecular Mass

17 - 22 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by an alkaline phosphatase activity assay using CCL-226 cells is ≥ 250 units/mg (EC50 ≤ 4 μg/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.