Product Code: GFC0034
Description
C-X-C motif chemokine ligand 8 (CXCL8) is a member of the CXC subfamily of chemokines and is produced by leukocytic cells (monocytes, T cells, neutrophils, and natural killer cells) and non-leukocytic somatic cells (endothelial cells, fibroblasts, and epithelial cells), with the most prominent source being monocytes and macrophages. It activates neutrophils inducing chemotaxis, exocytosis, and the respiratory burst. CXCL8 is considered one of the most potent neutrophil chemoattractants in inflammation and binds to two different chemokine receptors on leukocytes: the G protein-coupled receptors CXCR1 and CXCR2. CXCL8 is reported to promote breast cancer progression by increasing cell invasion, angiogenesis, and metastasis and has been reported to be involved in regulating breast cancer stem-like cells. It also has proangiogenic properties in inflammatory diseases of the conjunctiva, cornea, iris, retina, and orbit.
Specification
