Cytokines

Human CX3CL1

Product Code: GFC0030

Description

C-X3-C motif chemokine ligand 1 (CX3CL1) is a unique chemokine belonging to the CX3C family, and is characterized by a C-X3-C cysteine motif within the chemokine domain, near the amino terminus of the protein. CX3CL1 is upregulated in endothelial cells by inflammatory signals and is synthesized as a membrane-bound molecule that mediates cell migration and adhesion. Cleavage at the base of the stalk by metalloproteinases generates a soluble chemokine, which functions as a potent chemoattractant of target cells. CX3CL1 has been implicated in pathology of inflammatory diseases, such as atherosclerosis and other vascular diseases, and has anti-apoptotic functions.

Specification

Source

CHO

Symbols

C3Xkine, Chemokine (C-X3-C motif) ligand 1, FKN, Neurotactin, NTN, NTT, SCYD1, Small inducible cytokine subfamily D member 1

Accession

P78423

AA Sequence

QHHGVTKCNITCSKMTSKIPVALLIHYQQNQASCGKRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAALTRNGGTFEKQIGEVKPRTTPAAGGMDESVVLEPEATGESSSLEPTPSSQEAQRALGTSPELPTGVTGSSGTRLPPTPKAQDGGPVGTELFRVPPVSTAATWQSSAPHQPGPSLWAEAKTSEAPSTQDPSTQASTASSPAPEENAPSEGQRVWGQGQSPRPENSLEREEMGPVPAHTDAFQDWGPGSMAHVSVVPVSSEGTPSREPVASGSWTPKAEEPIHATMDPQRLGVLITPVPDAQAATR

Molecular Mass

50 - 75 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by Ca2+ mobilization assay in CHO-K1/Gα15/hCX3CR1 cells is ≥ 666 units/mg (EC50 ≤ 1.5 μg/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.