Cytokines

Human CCL4

Product Code: GFC0011

Description

C-C motif chemokine ligand 4 (CCL4) is a member of the CC family of chemokines. It is predominantly synthesized by activated CD8+ T cells. CCL4 signals through CCR5, which is the major coreceptor required for entry of certain strains of HIV-1 into permissive cells, and it is known that HIV-1-specific CD8+ T cell clones that exhibit cytotoxic T lymphocyte (CTL) activity secrete CCL4 upon encountering sensitized target cells.

Specification

Source

E. coli

Symbols

ACT-2, Immune activation protein 2, LAG-1, Lymphocyte activation gene 1 protein, MIP-1b, Protein H400, SCYA2, SCYA4, Small-inducible cytokine A4, T-cell activation protein 2

Accession

P13236

AA Sequence

APMGSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQPAVVFQTKRSKQVCADPSESWVQEYVYDLELN

Molecular Mass

7.6 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by Ca2+ mobilization assay in CHO-K1/Gα15/hCCR5 cells is ≥ 1 x 10^4 units/mg (EC50 ≤ 0.1 μg/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.