Cytokines

Human BTC

Product Code: GFC0007

Description

Betacellulin encoded by BTC gene is a member of the epidermal growth factor (EGF) family, and signals through EGF receptor and ERBB4. It activates ERK and AKT pathways, which induces neural stem cell proliferation and prevents spontaneous differentiation in culture. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability.

Specification

Source

E. coli

Symbols

BTC

Accession

P35070

AA Sequence

MDGNSTRSPETNGLLCGDPEENCAATTTQSKRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFY

Molecular Mass

9.1 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by a cell proliferation assay using BALB/c 3T3 cells is ≥ 1.0 x 10^8 units/mg (EC50 ≤ 0.01 ng/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.