Cytokines

Human AREG

Product Code: GFC0001

Description

Amphiregulin encoded by the AERG gene is a member of the epidermal growth factor (EGF) family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development.

Specification

Source

HEK293

Symbols

ARB, CRDGF, SDGF, AREG

Accession

Q5U026

AA Sequence

SVRVEQVVKPPQNKTESENTSDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSK

Molecular Mass

11.3 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by a cell proliferation assay using BALB/c 3T3 cells is ≥ 5.0 x 10^6 units/mg (EC50 ≤ 0.2 ng/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.