Forskolin

Product Code: CB0456

Catalog Number	Unit Size	Price
CB0456-10 mg	10 mg	Online Inquiry
CB0456-50 mg	50 mg	Online Inquiry

Description

Forskolin, or coleonol, is a cell-permeable, potent, reversible and rapid activator of adenylyl cyclase, an enzyme that converts ATP to cAMP and pyrophosphate. In combination with 5 other compounds (Valproic acid, sodium salt, RepSox, Tranylcypromine hydrochloride, CHIR 99021 and 3-Deazaneplanocin A hydrochloride), forskolin enables chemical reprogramming of mouse embryonic fibroblasts to pluripotent stem cells, without genetic factors. In combination with IBMX, forskolin induces neural differentiation of mesenchymal stem cells by downregulating neuron restrictive silencer factor.

Specification

Chemical Name

(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one

Formula

C22H34O7

Molecular Weight

410.51

Purity

≥98% (HPLC)

CAS No.

66575-29-9

PubChem

47936

InChi Key

OHCQJHSOBUTRHG-KGGHGJDLSA-N

SMILES String

O=C1C[C@](C)(C=C)O[C@]2(C)[C@@H](OC(C)=O)[C@@H](O)[C@@]3([H])C(C)(C)CC[C@H](O)[C@]3(C)[C@]21O

Storage

Store at -20°C. Store under desiccating conditions.

For research or further manufacturing use only. Not for use in humans.