DAPT

Product Code: CB0434

Catalog Number	Unit Size	Price
CB0434-10 mg	10 mg	Online Inquiry
CB0434-50 mg	50 mg	Online Inquiry

Description

DAPT is a γ-secretase inhibitor. DAPT blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC) and causes ESCs to commit to neuronal differentiation. DAPT can be used in a small molecule cocktail to derive cortical neurons from hPSCs and to maintain hepatocytes in culture. DAPT also promotes the formation of cone photoreceptors in retinal organoids.

Specification

Chemical Name

(2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine 1,1-dimethylethyl ester

Formula

C23H26F2N2O4

Molecular Weight

432.46

Purity

≥99% (HPLC)

CAS No.

208255-80-5

PubChem

5311272

InChi Key

DWJXYEABWRJFSP-XOBRGWDASA-N

SMILES String

CC(C)(C)OC([C@H](C1=CC=CC=C1)NC([C@H](C)NC(CC2=CC(F)=CC(F)=C2)=O)=O)=O

Storage

Store at 2-8°C. Store under desiccating conditions.

For research or further manufacturing use only. Not for use in humans.