Recombinant Human IFN-γ

Product Code: GFC0064

Catalog Number Unit Size Price
GFC0064-20µg 20µg Online Inquiry
GFC0064-100µg 100µg Online Inquiry
GFC0064-250µg 250µg Online Inquiry
GFC0064-500µg 500µg Online Inquiry
GFC0064-1mg 1mg Online Inquiry

Description

IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells, and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ is species-specific and is biologically active only in human and primate cells. Recombinant Human IFN-γ is a 16.8 kDa protein containing 144 amino acid residues.

Specification

Sample Resource
E.coli
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Synonyms
Immune Interferon, type II interferon, T cell interferon, MAF
AA Sequence
MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ
Biological Activity
Assay #1: Determined by its ability to induce STAT1/STAT2 activation in Human COLO 205 ISRE LUC reporter cells.

Assay #2: The ED50 determined by a cytotoxicity assay using HT-29 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
Calculated Molecular Weight
16.8 kDa
Accession Number
P01579.1
Gene ID
3458
Endotoxin
Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)
For research or further manufacturing use only. Not for use in humans.

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