Recombinant Human FGF-10 Protein

Product Code: GFC0038

Catalog Number Unit Size Price
GFC0038-25 ug 25 ug Online Inquiry
GFC0038-250 ug 250 ug Online Inquiry

Description

Fibroblast Growth Factor 10 (FGF-10) is an evolutionary conserved secreted growth factor mediating mostly mesenchymal to epithelial signaling. FGF-10 belongs to the heparin binding FGF family, and is also known as Keratinocyte Growth Factor-2 (KGF-2). It shares homology with KGF and receptor binding to FGFR2-IIIb. However, while KGF induces proliferation and differentiation of various epithelial cells, FGF-10 promotes budding and branching morphogenesis during the multi-organ development via mesenchymal-epithelial cell interactions. FGF-10 is critical for lung and limb development, and is regulated by Shh during early development.

Specification

Source
E. coli-derived human FGF-10 protein, Cys37-Ser208 & Gly41-Ser208
Reactivity
Human
N-terminal Sequence
Cys37 & Gly41
Purity
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining.
Molecular Mass (Predicted)
19.5 kDa
SDS-PAGE
19-22 kDa, reducing conditions
Accession
O15520
Biological Activity
Measured in a cell proliferation assay using 4MBr‑5 rhesus monkey epithelial cells. Rubin, J.S. et al. (1989) Proc. Natl. Acad. Sci. USA 86:802. The ED50 for this effect is 20-100 ng/mL.
Endotoxin
<0.10 EU per 1 μg of the protein by the LAL method.
Application
Bioactivity
For research or further manufacturing use only. Not for use in humans.

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