Recombinant Human Flt-3 Ligand/FLT3L Protein, E. coli-derived, GMP grade

FMS-like tyrosine kinase 3 ligand (Flt-3 Ligand) is growth factor that stimulates the proliferation and differentiation of hematopoietic multipotent progenitors and promotes proliferation of NK cells and dendritic cell subgroups by combining with other growth factors.
Flt3L is produced by T cells and stromal fibroblasts, and targets a variety of cells including hematopoietic stem cells, B cells, T cells, dendritic cells, and NK cells. FLT3LG is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1).
FLT3LG acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. FLT3LG cooperates with IL2, IL6, IL7, and IL15 to induce NK cell development and with IL3, IL7 and IL11 to induce terminal B cell maturation.